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Hans Anton Lehr Selected Research

pralnacasan

7/2007The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression.
2/2004The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation.

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Hans Anton Lehr Research Topics

Disease

4Colitis
09/2010 - 06/2002
3Inflammation (Inflammations)
09/2010 - 06/2002
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
09/2010 - 02/2004
1Breast Neoplasms (Breast Cancer)
01/2015
1Asthma (Bronchial Asthma)
08/2008
1Pneumonia (Pneumonitis)
08/2008
1Respiratory Hypersensitivity
08/2008
1Body Weight (Weight, Body)
07/2007
1Malaria
03/2005
1Nasal Polyps (Nasal Polyp)
01/2005
1Edema (Dropsy)
01/2005
1Autoimmune Diseases (Autoimmune Disease)
04/2003
1Crohn Disease (Crohn's Disease)
04/2003
1Disease Resistance
06/2002
1Obesity
06/2002

Drug/Important Bio-Agent (IBA)

5CytokinesIBA
09/2010 - 06/2002
4Dextran SulfateIBA
09/2010 - 06/2002
2Interleukin-1beta (Interleukin 1 beta)IBA
09/2010 - 02/2004
2Interleukin-18 (Interleukin 18)IBA
09/2010 - 02/2004
2pralnacasanIBA
07/2007 - 02/2004
2IceIBA
07/2007 - 02/2004
1Hormones (Hormone)IBA
01/2015
1InflammasomesIBA
09/2010
1Dextrans (Dextran)FDA Link
09/2010
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
09/2010
1AllergensIBA
08/2008
1Interleukin-2 (IL2)IBA
08/2008
1Interleukin-2 Receptors (IL 2 Receptor)IBA
08/2008
1Interleukin-13IBA
08/2008
1Interleukin-2 Receptor beta SubunitIBA
08/2008
1Caspase 1 (ICE Protease)IBA
07/2007
1ElementsIBA
07/2007
1Messenger RNA (mRNA)IBA
07/2007
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2007
1AntioxidantsIBA
03/2005
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
03/2005
1urinastatin (MR 20)IBA
03/2005
1Tocopherols (Tocopherol)IBA
03/2005
1Protease Inhibitors (Protease Inhibitor)IBA
03/2005
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
01/2005
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2005
1InterleukinsIBA
02/2004
1Drinking WaterIBA
02/2004
1Enzyme Inhibitors (Inhibitors, Enzyme)IBA
02/2004
1Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric
04/2003
1Immunosuppressive Agents (Immunosuppressants)IBA
04/2003
1Azathioprine (Imuran)FDA LinkGeneric
04/2003
1ChemokinesIBA
06/2002
1Sulfonic AcidsIBA
06/2002
1LeptinIBA
06/2002

Therapy/Procedure

2Oral Administration
09/2010 - 07/2007
1Adjuvant Chemotherapy
01/2015
1Therapeutics
08/2008
1Organ Transplantation
04/2003